Recent progress in NIR-Ⅱ emitting lanthanide-based nanoparticles and their biological applications

作者：Suwan Ding; Lingfei Lu; Yong Fan^*; Fan Zhang^*

来源：Journal of Rare Earths, 2020, 38(05): 451-463.

The second near-infrared(NIR-Ⅱ,1000-1700 nm) window provides a superior optical platform with high resolution,deep penetration and high signal-to-noise ratios(SNRs),which results from the intrinsic low scattering and auto fluorescence in biological tissues.As one of the promising NIR-Ⅱ emitting probes,lanthanide based nanoparticles(LnNPs) exhibit high photo stability and chemostability,long photoluminescence lifetimes,low long-term cytotoxicity and narrow emission bandwidths.All these merits have spurred the evolution of related bio-optics and a variety of biomedical applications of LnNPs.This mini-review discusses the most recent advances in both the design-the composition and surface modifications-and the applications of NIR-Ⅱ emitting LnNPs in bioimaging,disease diagnosis and therapy.We also summarize the current limits and challenges facing the applications of LnNPs as well as discuss the directions of future development.

• 单位
  复旦大学; 聚合物分子工程国家重点实验室