科研之友
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摘要
Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33 days. Tubular diameter and epithelial height are reduced, subsequently they tend to increase without returning to normal values. The count and sperm morphology fluctuate along the exposure time. Lipoperoxidation levels of spermatozoa and testicular parenchyme are reduced. Therefore, we can conclude that exposure to CSHH induce damage in the seminiferous epithelium, decrease of lipoperoxidation in spermatozoa and testicular tissue, and damages the testicular and sperm morphology La disminuci車n del aporte de O2 a los tejidos provoca da os de 谷stos, incluido el epitelio semin赤fero. 迆ltimamente, se ha incrementado la poblaci車n que trabaja a gran altura, interesando as赤 el estudio de la hipoxia hipob芍rica sobre la espermatog谷nesis. Para este estudio se utilizaron dos grupos de ratones machos sexualmente maduros: Control (540 metros sobre el nivel del mar (msnm)) y grupo con hipoxia hipob芍rica simulada cr車nica (HHSC) (4.600 msnm) expuestos por 8, 16, 24 車 33 d赤as. Fueron evaluados hematocrito, reticulocitosis, peso de test赤culos, epid赤dimos y ves赤cula seminal; altura del epitelio semin赤fero, di芍metro tubular, recuento y morfolog赤a esperm芍tica y lipoperoxidaci車n de membranas de espermatozoides y par谷nquima testicular. El peso de test赤culos, epid赤dimos y ves赤cula seminal se redujo para empezar a recuperarse a los 33 d赤as. El di芍metro tubular y la altura del epitelio se redujeron y luego tendieron a aumentar sin normalizarse. El recuento y la morfolog赤a esperm芍ticos fluctaron en el tiempo. Se puede concluir que la exposici車n a HHSC induce da o del epitelio semin赤fero, disminuci車n de la lipoperoxidaci車n en espermatozoides y tejido testicular, y altera la morfolog赤a testicular y esperm芍tica
