溶解自身以保护群体:细菌噬菌体防御中的cGAS泛素样偶联机制（英文）

作者：王俊轶^*; 李国平^*; 吴敏^*

来源：Science Bulletin, 2023, 68(19): 2132-2134.

<正>In a recent paper published in Nature, Jenson et al. [1] reported that CD-NTases-associated protein 2(Cap2) regulates the activity of bacterial cyclic GMP-AMP synthase(c GAS)-like enzymes in a manner analogous to ubiquitination, boosting the production of the second messenger cyclic GMP-AMP(c GAMP) to enable antiphage immunity. The ubiquitin-like conjugation system serves as a countermeasure to phage evasion strategy that sequesters c GAMP to block downstream phospholipase activation, thereby enhancing bacterial defense(Fig. 1) [1].

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  中国科学院大学