The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin‐induced apoptosis is mediated via suppression of the Ras/ ERK and Ras/ mTOR pathways

作者：Masanobu Tsubaki; Daichiro Fujiwara; Tomoya Takeda; Toshiki Kino; Yoshika Tomonari; Tatsuki Itoh; Motohiro Imano; Takao Satou; Katsuhiko Sakaguchi; Shozo Nishida

来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2017, 44(2): 222-234.

DOI：10.1111/1440-1681.12690

• Bim
• extracellular signal regulated‐protein kinase ?
• mammalian target of rapamycin
• Ras
• statins

Summary(#br)Statins induce apoptosis of tumour cells by inhibiting the prenylation of small G‐proteins. However, the details of the apoptosis‐inducing mechanisms remain poorly understood. The present study showed that the induction of apoptosis by statins in four different human head and neck squamo...