β-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditionsβ-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditionsβ-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditionsβ-Alanine-DBU＂ A Highly Efficient Catalytic System forKnoevenageI-Doebner Reaction under Mild Conditions

作者：祝令建; 雷宁; 缪震元; 盛春泉; 庄春林; 姚建忠; ***

来源：Chinese Journal of Chemistry, 2012, 30(1): 139-143.

• 催化系统
• 高效催化
• 温和条件
• 反应
• 丙氨酸
• Knoevenagel
• 不饱和羧酸
• 氮杂双环

A mild and efficient Knoevenagel-Doebner reaction from malonic acid and a wide range of aldehydes was catalyzed by a catalytic system consisting offlalanine and 1,8-diazabicyclo[5.4.0]undec-7-ene （DBU）, affording the corresponding （E）-a,fl-unsaturated carboxylic acids in good to excellent yields and with high stereoselectivity. The advantage of the method is that the reaction could proceed smoothly at ambient temperature so that it can tolerate a variety of functional groups and avoid unnecessary side reactions.

• 单位
  中国人民解放军第二军医大学