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摘要
Background: Psychosocial and scoial factors are important participators in the pathogenesis of post-stroke depression(PSD).However,the fact that cognitive,emotional and behavioral changes brought by stigma may be closely related to PSD has received little attention.Objective: To explore the correlation between stigma and PSD in initally diagnosed stroke patients.Methods: In this cross-sectional study,by use of convenience sampling,initially diagnosed stroke patients(n=299) were recruited from Neurology and Neurosurgery Departments of Nanfang Hospital,Southern Medical University and Guangdong 999 Brain Hospital from July to December 2019.Socio-demograpchics and stroke-related history were collected.The stigma,depression and severity of disability at the end of 1-month follow-up were evaluated using the Stroke Stigma Scale(SSS),Patient Health Questionnaire-9 (PHQ-9) and modified Rankin Scale (mRS),respectively.Results: 78 cases were excluded due to loss to follow-up,other 221 cases who completed the follow-up were included for final analysis.By PHQ-9 score,65(29.4%) and 156(70.6%) were evaluated with and without PSD,respectively.PSD patients experienced higher score of physical impairment,social isolation,discrimination experience,internalized stigma,and scores of SSS,PHQ-9,and mRS than non-PSD patients(P<0.05).Correlation analysis revealed that PHQ-9 score was positively correlated with score of SSS,physical impairment,social isolation,discrimination experience,internalized stigma,and mRS,respectively(rs=0.606,0.319,0.441,0.369,0.616,0.389,P<0.05).Multivariate Logistic regression analysis illustrated that score of SSS was an independent associated factor of PSD in initally diagnosed stroke patients〔OR=1.263,95%CI(1.158,1.379),P<0.05〕.Conclusion: Stigma manifested in the early stage of stroke may be used as a predictor of PSD in initally diagnosed stroke patients.So medical workers and family members of the stroke patient should be on fully alert for PSD.
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