科研之友
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摘要
objectives: to examine the relationship between chronic bacterial infection and pulmonary hypertension, using doppler echocardiography, in patients with cystic fibrosis (cf). methods: a prospective cross-sectional study involving cf patients (%26gt;16 years of age) admitted to a program for adults with the disease. the study included 40 patients with a mean age of 23.7 ㊣ 6.3 years. patients were submitted to clinical evaluation, doppler echocardiography, pulmonary function tests, chest x-rays and sputum cultures of pseudomonas aeruginosa and burkholderia cepacia. results: in terms of the following variables, no significant differences were found between p. aeruginosa-positive patients and p. aeruginosa-negative patients: clinical score (p = 0.472); forced expiratory volume in one second (fev1; p = 0.693), radiological score (p = 0.760); tricuspid regurgitant jet velocity (trv, p = 0.330); diameter of the right ventricle (drv, p = 0.191); and right ventricular/pulmonary artery (rv/pa) systolic acceleration time (sat, p = 0.330). b. cepacia-positive patients presented significantly lower fev1 than did b. cepacia-negative patients (p = 0.011). no significant differences were found between b. cepacia-positive patients and b. cepacia-negative patients regarding the following variables: clinical score (p = 0.080); radiological score (p = 0.760); trv (p = 0.613); drv (p = 0.429); and rv/pa sat (p = 0.149). conclusions: chronic infection with p. aeruginosa or b. cepacia presented no association with pulmonary hypertension in adult cf patients. pulmonary function was worse in b. cepacia-positive patients than in p. aeruginosa-positive patients.
