Avaliaˋˋo do teste de nitrato redutase para a detecˋˋo r芍pida de resist那ncia aos medicamentos de primeira linha em cepas de Mycobacterium tuberculosis isoladas de pacientes em um hospital geral

作者：Mansur; Maria de Fatima Filardi Oliveira; Carvalho; Wania da Silva; Silva; Raquel Bandeira da; Preta; Rodrigo Gonalves Cata; Fernandes Junior; Lucas Almeida; Miranda; Silvana Spindola de

来源：Jornal Brasileiro de Pneumologia, 2012.

DOI：10.1590/S1806-37132012000200010

• mycobacterium tuberculosis
• microbial sensitivity tests
• tuberculosis
• multidrug-resistant
• nitrate reductase.

we compared the nitrate reductase assay with the proportion method, which is considered the gold standard, in 57 mycobacterium tuberculosis strains isolated from patients treated at the federal university of minas gerais hospital das cl赤nicas, located in the city of belo horizonte, brazil. for rifampin and isoniazid, the sensitivity, specificity, and accuracy of the nitrate reductase assay were all 100%, whereas they were 100%, 88.9%, and 66.7%, respectively, for streptomycin and 98.0%, 100%, and 98.2%, respectively, for ethambutol. the mean time to results was ten days. in the study sample, the nitrate reductase assay proved highly accurate and showed excellent concordance with the gold standard.