Application of Molecular Imprinting Technology in Post-translational Modified Protein Enrichment

作者：Zhang, Pan; Jiang, Li-Yan; Ma, Jiu-Tong^*; Jia, Qiong^*

来源：Chinese Journal of Analytical Chemistry, 2021, 49(1): 24-33.

DOI：10.19756/j.issn.0253-3820.201369

• Molecular imprinting technology
• Protein
• Post-translational modification
• Enrichment
• Review

Post-translational modification of proteins plays an important regulatory role in the process of cell life, enabling proteins to have biological activities and perform corresponding functions. The content of posttranslational modification proteins in the organism is very low, which makes it commit to a mighty challenge to accurately identify the post-translational modification proteins. The molecularly imprinted cavity, which is perfectly matched with the size, shape and functional groups of the target molecules, has shown great potential in the separation of modified proteins. In this paper, the types and characteristics of post-translational modified proteins and molecular imprinting methods are summarized. On this basis, the application of molecularly imprinted polymers in the enrichment of post-translational modified proteins is reviewed, and the prospect of its development is prospected.

• 单位
  吉林大学