科研之友
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摘要
objective: to assess airway hyperresponsiveness to 4.5% hypertonic saline solution in comparison to that obtained through challenge with other bronchoconstriction agents and in relation to patient allergic sensitization. methods: a cross-sectional, experimental study was conducted, initially involving 85 subjects. after exclusions, the final sample consisted of 62 patients, divided into two groups: a study group of those with asthma (n = 45) and a control group of those with no asthma or allergies (n = 17). hypertonic saline was nebulized using an ultrasonic nebulizer and administered successively for 0.5, 1, 2, 4 and 8 minutes until a drop in forced expiratory volume in one second of = 15% was achieved in relation to the baseline value. the level of specific immunoglobulin e to dermatophagoides pteronyssinus level was determined by immunocap assay and was considered positive when %26gt; 0.35 ku/l. results: in the 36 asthma group subjects presenting a response, the mean drop in forced expiratory volume in one second after hypertonic saline nebulization was 27.4%. none of control group subjects (immunoglobulin e %26lt; 0.35 ku/l) presented a positive response to hypertonic saline. the mean forced expiratory volume in one second for control group subjects was 9%. the results of a bronchial provocation test were negative in 9 of the asthma group subjects. the frequency of bronchial provocation test positivity was higher in the subjects presenting elevated levels of specific immunoglobulin e, indicating that there is a relationship between bronchial hyperresponsiveness and the level of specific immunoglobulin e. the sensitivity and specificity of the test were 80% and 92%, respectively. conclusion: bronchial provocation with hypertonic saline presents satisfactory sensitivity and specificity. therefore, in addition to being a low cost procedure that requires very little equipment, it is a useful means of assessing hyperresponsiveness in children and adolescents.
