体外循环和细胞凋亡:病理生理及防治研究进展

作者：施珊珊; 舒强; 方向明

来源：国际麻醉学与复苏杂志, 2006, (03): 164-166.

DOI：10.3760/cma.j.issn.1673-4378.2006.03.011

• cardiopulmonary bypass
• neutrophil
• myocardium
• apoptosis

Cardiopulmonary bypass (CPB) delays neutrophil apoptosis, while inducing apoptosis in myocardium. The former plays a significant role in inducing and maintaining the systemic inflammatory reaction (CPB-SIR), and the latter is the main mechanism in arousing ischemia-reperfusion injury. CPB-SIR could be alleviated by inhibition delay apoptosis in neutrophils, while prevention and diminution myocardial apoptosis improves postoperative cardiac function.

• 单位
  浙江大学医学院附属邵逸夫医院; 浙江大学医学院附属儿童医院