Tetroazolemycins A and B, Two New Oxazole-Thiazole Siderophores from Deep-Sea Streptomyces olivaceus FXJ8.012

作者：Liu, Ning; Shang, Fei; Xi, Lijun; Huang, Ying^*

来源：Marine Drugs, 2013, 11(5): 1524-1533.

DOI：10.3390/md11051524

• deep-sea water
• Streptomyces olivaceus
• tetroazolemycin
• siderophore

Two new oxazole/thiazole derivatives, named tetroazolemycins A (1) and B (2), have been isolated from the acetone extract of the mycelium of Streptomyces olivaceus FXJ8.012 derived from deep-sea water, together with three known compounds, spoxazomicins A-C (3-5), isolated from the fermentation supernatant. The planar structure and relative configuration of tetroazolemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques, and showed to be new pyochelin-type antibiotics. Both compounds showed metal ion-binding activity and their Zn2+ complexes exhibited weak activity against pathogenic bacteria Klebsiella pneumoniae.

• 单位
  微生物资源前期开发国家重点实验室; 中国科学院微生物研究所; 北京化工大学