科研之友
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摘要
objective: to evaluate compliance in children with acute lymphoblastic leukemia. method: compliance was assessed through specific interviews. results: a total of 73 patients, aged under 18 and who had concluded the maintenance phase of chemotherapy, were enrolled on the study. eighty-one per cent of the interviews were conducted with the patients%26apos; mothers; 92% of the families stated that medical instructions had been understood well. interviews indicated that 27% of the patients did not receive their medication twice or more during the maintenance phase, without medical direction for this. these children were considered non-compliant. sixteen per cent of the children failed to receive their medication three times or more. the main reason for non-compliance was forgetfulness. in ten cases the reported dosage of drugs was not that which was prescribed. no significant associations of non-compliance with parents%26apos; schooling level, number of family members or per capita family income were detected. the 8.5-year estimated probability of event free survival was 72.4% (95% ci: 59.2-82.3). the event free survival curves for non-compliant children were not statistically different from those for the compliant group. conclusions: results suggest that comprehensive approaches to the problem of non-compliance are urgently needed.
