科研之友
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摘要
background: despite recent discoveries concerning molecular alterations involved in astrocytoma tumorigenesis, the conventional histological analysis remains the best diagnostic method and a reasonable prognostic indicator for astrocytic tumors. however, the histopathological routine recommended by the world health organization (who) is laborious and marked by low reproducibility. objective: the present study aimed to develop auxiliary strategies for astrocytic tumor graduation according to histological criteria established by who. material and method: a clinical and epidemiological analysis and a histopathological evaluation were performed in 55 astrocytomas of different graduations (13 grade i, 14 grade ii, seven grade iii, 21 grade iv) and five samples of non-tumor tissue (control group). results: the distribution by age, sex, and tumor localization of astrocytomas in patients reproduced, in a general way, worldwide trends. the presence of multinucleated cells and gemistocytes was associated with tumoral malignancy. the histopathological findings evaluated through semi-quantitative criteria and cart modeling confirmed the primary classification, reaffirming their applicability and reproducibility. conclusion: these results indicate the cart decision tree and the totality of semi-quantitative scores as practical and auxiliary strategies for astrocytoma graduation as stated by who criteria.
