非谷氨酸受体依赖的钙毒性机制在急性脑缺血损伤中的作用

作者：向军; 唐宇平; 蔡定芳

来源：中国病理生理杂志, 2010, (06): 1224-1228.

• 酸敏感离子通道
• Na -Ca2 交换体
• 瞬时受体电位
• 脑缺血
• 钙 Acid sensing ion channels
• Na -Ca2 exchanger
• Transient receptor potential
• Brain ischemia
• Calcium

Intracellular Ca2 overload and the following Ca2 -toxicity are an important mechanism underlying ischemic brain injury.However,recent clinical trials using antagonists of the N-methyl-daspartate(NMDA) to prevent ischemic brain injury in humans have been largely disappointing.Activation of glutamate...

• 单位
  复旦大学附属中山医院; 复旦大学