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摘要
Se reportan los hallazgos encontrados a partir de NeuroSPECT en trastornos del 芍nimo, incluyendo trastorno bipolar, depresi車n mayor y auto-mutilaci車n. Se compararon los resultados de una muestra de 29 pacientes con trastorno afectivo en espectro bipolar complicado con conductas auto-mutilatorias, un grupo de 20 pacientes bipolares sin auto-mutilaci車n y 22 pacientes depresivos sin auto-mutilaci車n. Dentro de los hallazgos destaca la asociaci車n entre trastornos del 芍nimo y auto-mutilaci車n con hiper-perfusi車n tal芍mica bilateral en el segmento dorso-ventral-anterior, asociado a hipo-perfusi車n en corteza peri-l赤mbica (芍reas 32, 24 y 23 de Brodmann). Los m迆ltiples reportes que relacionan, tanto en animales como en humanos, las conductas auto-mutilatorias con fen車menos de hipo-algesia, anestesia o disestesias, permiten hipotetizar la participaci車n de una disfunci車n en circuitos t芍lamo-peri-l赤mbicos asociados a v赤as nocioceptivas y a conciencia ※somato-ps赤quica§ y su relaci車n con fen車menos auto-mutilatorios.We report NeuroSPECT findings in mood disorders, including bipolar disorder, major depression and self-mutilation. We compare results in 29 patients with bipolar disorder complicated by self-mutilation, a group of 20 patients with bipolar disorder uncomplicated and 22 patients with mayor depression uncomplicated by self-mutilation. Among the NeuroSPECT findings we report the association of mood disorders and self-mutilation with hyperperfusion of the anterior-dorsal-ventral segment of both thalami concomitant with hypoperfusion in perilimbic cortex, namely areas 32, 24 (anterior cingulate gyrus) and 23 of Brodmann. Multiple reports in the literature relate both, in animals and man, self-mutilation with phenomena of hypoalghesia, anesthesia, or dysestesias and are the basis for our hypothesis linking dysfunction of limbic-thalamic circuits, associated with nocioceptive fibers, somato-psychic consciousness and self-mutilation phenomena.
