Protoporphyrin Ⅸ and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

作者：Chenjian Gu; Yang Wu; Huimin Guo; Yuanfei Zhu; Wei Xu; Yuyan Wang; Yu Zhou; Zhiping Sun; Xia Cai; Yutang Li; Jing Liu; Zhong Huang; Zhenghong Yuan; Rong Zhang; Qiang Deng; Di Qu; Youhua Xie

来源：Chinese Science Bulletin, 2021, 66(9): 925-936.

• SARS-CoV-2
• ACE2
• Protoporphyrin Ⅸ
• Verteporfin

The SARS-CoV-2 infection is spreading rapidly worldwide.Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed.Here,we discovered that protoporphyrin Ⅸ (PpⅨ) and verteporfin,two

• 单位
  中国科学院大学; 复旦大学; 中国医学科学院北京协和医院