Palladium‐Catalyzed C?H Alkenylation of Arenes with Alkynes: Stereoselective Synthesis of Vinyl Chlorides via a 1,4‐Chlorine Migration

作者：Zhen Li; Prof. Dr. Wei‐Liang Duan

来源：Angewandte Chemie, 2018, 130(49): 16273-16277.

DOI：10.1002/ange.201808866

• 1
• 4-Chlorverschiebung
• Alkine
• C-H-Aktivierung
• Ligandbeschleunigte Katalyse
• Palladium

A directing group‐free, ligand‐promoted palladium‐catalyzed C?H arylation of internal alkynes with simple arenes was developed. Alkenyl chlorides resulting from a 1,4‐chlorine migration or trisubstituted alkenes were produced in moderate to good yields depending on the type of alkyne.

• 单位
  金属有机化学国家重点实验室