Sepse neonatal precoce: n赤veis de citocinas no sangue de cordˋo umbilical no diagn車stico e durante o tratamento

作者：Campos; Dulcimar P; Silva; Marcos V; Machado; Juliana R; Castellano; Lucio R; Rodrigues; Virmondes; Barata; Cristina H C

来源：Jornal de Pediatria, 2010.

DOI：10.1590/S0021-75572010000600011

• early-onset sepsis
• neonates
• cytokines
• tnf-&alpha
• il-10.

objective: to assess clinical and laboratory parameters and serum cytokine levels in 55 neonates who developed early-onset sepsis. methods: clinical parameters associated with early-onset neonatal sepsis were assessed. white blood cell differential and serum c-reactive protein and glucose levels were measured upon diagnosis of sepsis and 48 hours later. il-1汕, il-10, il-6, and tnf-汐 levels were measured in cord blood samples obtained on the day of diagnosis and from samples collected 48 and 96 hours after treatment onset. results: among newborns with early-onset sepsis, the length of hospital stay was inversely correlated with birth weight. clinical parameters varied widely, especially body temperature. blood glucose changes - particularly hypoglycemia - were common. leukopenia, usually due to neutropenia, was the most prevalent change in blood cell count. c-reactive protein levels correlated with the immature-to-total neutrophil ratio. serum tnf-汐 and il-10 levels measured early in the course of sepsis were positively correlated with those detected in cord blood. conclusions: clinical and laboratory parameters varied widely among neonates with sepsis in this sample. in neonates who presented with increased cytokine levels at birth, this abnormality persisted throughout the infectious process.