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摘要
the objective of the present work was to characterize morphological, morphometrical and stereologically the hepatic alterations in rat fetuses, caused by the administration of albendazole during pregnancy. they were obtained fetuses of wistar rats, which received in days 9, 10 and 11 of pregnancy a daily dose of 5 mg/kg body weight of albendazole. the control rats received injections of saline in the same days. at the 20th day, the rats were sacrificed by anesthetic ether inhalation, the fetuses were removed and immediately fixed in alfac for 24 h. all the fetuses, uteri and placentas, after fixed, was dried in filter paper and weighed in a precision scale, whereas the umbilical cords were measured with a vernier. the bodies were longitudinally cut and embedded in paraffin. six mm-thick serial sections were stained with hematoxylin and eosin. in addition to the histopatologic examination, histometric technics were used. the obtained results, in the used experimental conditions, suggest that prenatal exposition to albendazole directly acts on the embryogenesis, causing malformations, like agenesia of the tail and hydropic fetuses. in those fetuses without malformations, the drug acts on the fetal growth, causing modifications characterized by reduced body weight, placental weight and size of the umbilical cord, as well as structural alterations of the hepatic tissue, translated by smaller hepatocytes with smaller nuclei, and scanty cytoplasm but increased number density. the megacariocytes were more volumous, with greater lobulated nuclei, occupying a higher relative volume. the sinusoids occupied a similar relative volume in the fetuses of both studied groups. the treated fetuses, in addition to the malformations appeared to be immature, when compared to the controls
