It's T Time for Normal Blood Vessels

作者:Thienpont Bernard*; Lambrechts Diether*
来源:Developmental Cell, 2017, 41(2): 125-126.
DOI:10.1016/j.devcel.2017.04.005

摘要

In a new report in Nature, Tian and colleagues (2017) describe that T cell activation in tumors induces blood vessel normalization. Because abnormal vasculature in tumors is known to reduce chemotherapy effectiveness and T lymphocyte infiltration and to increase metastasis, this suggests an exciting novel angle for checkpoint immunotherapy.