科研之友
微信
新浪微博
Facebook
分享链接
摘要
in patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-trna synthetase (anti-ars) antibodies marks the presence or predicts the development of interstitial lung disease (ild). a distinct clinical entity-antisynthetase syndrome-is characterized by the presence of anti-ars antibodies, myositis, ild, fever, arthritis, raynaud%26apos;s phenomenon, and mechanic%26apos;s hands. the most common anti-ars antibody is anti-jo-1. more recently described anti-ars antibodies might confer a phenotype that is distinct from that of anti-jo-1-positive patients and is characterized by a lower incidence of myositis and a higher incidence of ild. among patients with antisynthetase syndrome-related ild, the response to immunosuppressive medications is generally, but not universally, favorable.
