Progress of correlation between human epidermal growth factor receptor 2 and colorectal cancer [人表皮生长因子受体 2 与结直肠癌相关性的研究进展]

作者：Ni Y.; Liu Y.; Cui B.^*

来源：肿瘤研究与临床, 2021, 33(8): 633-637.

DOI：10.3760/cma.j.cn115355-20200914-00529

• Colorectal neoplasms
• Human epidermal growth factor receptor 2
• Neoadjuvant therapy
• Targeted therapy

In recent years, the incidence and mortality rates of colorectal cancer are increasing year by year. With the deepening of molecular biology research and the discovery of driver genes, the treatment of colorectal cancer has gradually developed to the direction of individuation and precision. As the second member of the epidermal growth factor receptor family, human epidermal growth factor receptor 2 (HER2) is involved in the regulation of cell growth, reproduction and division and the control of tumor growth. This article reviews the correlation between expression of HER2 and colorectal cancer.