科研之友
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摘要
Cadmium Chloride (CdC1) is a teratogen which is commonly used in industry. Although it is well known to cause toxicity in testes, kidney, heart and liver, few studies have been carried out in the digestive system. In the present study the effects of CdC1 on the esophagus of rats were investigated Wistar albino rats weighing 180 - 200 g were used. The animals were divided into two groups; one group was administered 2 mg/kg/day CdC1 intraperitoneally for one week. Esophagus was removed and placed in 10% formaline. Sections were stained with Hematoxylene-Eosine and observed under light microscopy. Hyperplasia in the epithelium, an increase in fibrotic cells under epithelium, hemorrhage in vessels, free floating erythrocytes were all observed following fetal exposure. In conclusion and most importantly, cadmium chloride was found to cause an increase in connective tissue in esophagus mucosa. El cloruro de cadmio (CdCl2) es una sustancia teratog谷nica utilizada en la industria. Aunque es conocido por causar toxicidad en test赤culos, ri ones, coraz車n e h赤gado, pocos estudios se han realizado en el sistema digestivo. Se estudi車 el efecto del CdCl2 en el es車fago de ratas. Fueron utilizadas 24 ratas Wistar albinas de180-200 g. Los animales fueron divididos en dos grupos: a un grupo se le administr車 2 mg/kg/d赤a de CdCl2 v赤a intraperitoneal durante una semana, y un grupo control. Luego, el es車fago fue extra赤do y fijado en formalina al 10%. Las secciones fueron te idas con H-E, examin芍ndose al microscopio 車ptico. Se observ車 despu谷s de la exposici車n fetal, hiperplasia epitelial, con un aumento en las c谷lulas fibr車ticas en el epitelio y hemorragia en los vasos sin eritrocitos flotantes. Es importante destacar que el cloruro de cadmio caus車 incremento en el tejido fibroso de la mucosa esof芍gica.
