全脑神经元解析技术的评议（英文）

作者：Giorgio A.Ascoli; 霍冰星^*; Partha P.Mitra^*

来源：Science Bulletin, 2022, 67(09): 883-884.

<正>After an initial golden age typified by Cajal’s morphological classification of neuronal types based on Golgi’s stain at the turn of the twentieth century, followed by relative doldrums a few decades ago, Neuroanatomy has recently undergone a renaissance,driven by exponential decreases in storage and computing costs as well as major advances in biochemistry and microscopic techniques. This can be seen through citations of the term ‘‘connectomics” recently coined to denote the study of neuroanatomical connectivity, which retrieves nearly 8000 hits in PubMed and over 20,000 in Google Scholar in the 15 years since the term appeared in print [1]. It is broadly recognized that regional connectivity at the mesoscopic scale underlies distributed brain function and single neuron axonal projections underlie mesoscale connectivity [2,3].