科研之友
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摘要
background: liver cirrhosis is a common chronic disease that frequently runs with complications such as hepatocellular insufficiency, portal hypertension and hepatocellular carcinoma. objectives: to assess clinical and morphologic aspects of cirrhosis, establishing its associations with major histologic patterns and complications. material and method: 35 cirrhotic livers obtained from svoc-sp necropsies were studied, resulting in 2 distinct lesion patterns: cirrhosis associated to chronic hepatitis, and that related to steatohepatitis. the data obtained were mutually and individually analyzed according to each group. results and discussion: high incidence of cirrhosis in necropsies (7,1%) and high prevalence macronodules (62,8%) and of hcc (37,1%) among cirrhotic livers were observed, as when compared to previous studies. the histological analysis demonstrated a higher incidence of biliary aggression, hepatocyte siderosis, and hepatocyte neoducts in post-hepatitis cirrhosis. conclusions: this systematic approach to necroscopic specimens from the necroscopy public system yielded the detection of high frequency of cirrhosis, especially related to viral chronic hepatitis, with a potential impact in public health. high frequency of hepatocellular carcinoma, besides offering a model for future studies on hepatocarcinogenesis, clearly shows hcc as a major complication of cirrhosis.
