Inside Cover: Selenylation Chemistry Suitable for On‐Plate Parallel and On‐DNA Library Synthesis Enabling High‐Throughput Medicinal Chemistry (Angew. Chem. Int. Ed. 35/2022)

作者：Xu Hongtao; Wang Yan; Dong Hewei; Zhang Yiyuan; Gu Yuang; Zhang Shuning; Meng Yu; Li Jie; Shi Xiao Jie; Ji Qun; Liu Lili; Ma Peixiang; Ma Fei; Yang Guang; Hou Wei

来源：Angewandte Chemie - International Edition, 2022, 61(35): 202209209-1.

DOI：10.1002/ANIE.202209209

• Click Chemistry
• DNA-Encoded Library
• Modular Synthesis
• Selenium
• Selenylation

Selenium is an emerging versatile player in medicinal chemistry. In their Research Article (e202206516), Hongtao Xu, Fei Ma, Guang Yang, Wei Hou et?al. introduce a bioinspired SeClick chemistry between indole and benzoselenazole, which can be used in on‐plate parallel synthesis of indole‐selenide libraries and selenium containing DNA‐encoded libraries (SeDELs) in a modular and predictable way, thereby boosting the development of seleno‐medicinal chemistry in the near future.

• 单位
  上海交通大学; 浙江大学