Cannabinoid derivatives exert a potent anti‐myeloma activity both in vitro and in vivo

作者：M Victoria Barbado; Mayte Medrano; Teresa Caballero‐Velázquez; Isabel álvarez‐Laderas; Luis Ignacio Sánchez‐Abarca; Estefania García‐Guerrero; Jesús Martín‐Sánchez; Iván Valle Rosado; José Ignacio Piruat; Pedro Gonzalez‐Naranjo; Nuria Eugenia Campillo; Juan Antonio Páez; José Antonio Pérez‐Simón

来源：International Journal of Cancer, 2017, 140(3): 674-685.

DOI：10.1002/ijc.30483

• cannabinoids
• apoptosis
• caspases
• multiple myeloma
• ceramides

Although hematopoietic and immune system show high levels of the cannabinoid receptor CB2, the potential effect of cannabinoids on hematologic malignancies has been poorly determined. Here we have investigated their anti‐tumor effect in multiple myeloma (MM). We demonstrate that cannabinoids induce ...