光动力抗菌化学疗法治疗甲氧西林耐药金黄色葡萄球菌感染研究进展

作者：张永军; 方勇; 姚敏

来源：中华烧伤杂志, 2012, 28(5): 367-370.

DOI：10.3760/cma.j.issn.1009-2587.2012.05.014

• 光疗法
• 抗甲氧西林金黄色葡萄球菌
• 单态氧
• 光敏剂

This article reviews the advance in the research of both the mechanism of photodynamic antimicrobial chemotherapy (PACT) based on the principle of photodynamic therapy and the application of PACT in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection.Nowadays an inexorable prevalence of resistant bacteria observed worldwide,among which MRSA strains typically have a high potential of provoking outbreaks with intractability,makes it a pressing issue to develop new germicidal strategies.FACT is an emerging photochemistry-based technology.In the presence of oxygen,PACT,with the aid of the activation of photosensitizers to generate reactive oxygen species by the wavelength-specific light,destroys the structure of bacteria selectively and efficiently,with much lower bacterial resistance level than that of antibiotics.We expect that further research would elucidate the mechanism and develop clinical applications of PACT,and it may become a novel approach to solve the problem of MRSA infection in the future.

• 单位
  上海交通大学医学院附属第三人民医院