Quantum chemistry calculation on 5'-pTpTpCp-3'cleavage by Serine/Histamine amide

作者：Liu Hua-Nai^*; Wang Bing-Feng; Sun Ming; Zhang Lei

来源：Chemical Journal of Chinese Universities, 2007, 28(8): 1566-1569.

• L/D-Ser-Hism
• 5'-pTpTpCp-3'segment
• cleavage mechanism

A quantum chemistry calculation was carried out to study the mechanism of 5'-pTpTpCp-3' cleavage by the L/D-Ser-Hism. The effective molecular recognition between L/D-Ser-Hism and DNA through multi-hydrogen-bonds and the corresponding structural parameters were obtained. The results could be used to explain the mechanism of DNA cleavage by L/D-Ser-Hism.

• 单位
  中国科学院生物物理研究所; 华南理工大学; 华南农业大学