Two Cu(Ⅱ) and Co(Ⅱ)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation

作者：李靖; 李江涛^*

来源：Chinese Journal of Structural Chemistry, 2020, 39(10): 1849-1854.

DOI：10.14102/j.cnki.0254-5861.2011-2411

Two new Cu(II) and Co(II)-based coordination polymers with the chemical formulae of {Cu(L)2]·DMF}n(1) and {[Co(L)2]·2DMF}n(2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely [3,4?-bipyridine]-2?-thiol(HL). Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other, and shows 1-D microporous channels along the a axis. Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis. CCK-8 was used for the detection of cancer cells. Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells. The Annexin V-FITC/PI was recommended for cancer cell apoptosis, and the western blot was applied for the detection of PI3K/AKT pathway activation.