科研之友
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摘要
Objective: To study the prescription and preparation technology of Flos Magnoliae oil-based microemulsion gel, as well as its quality, transdermal absorption, anti-inflammatory and the antibacterial effect. Methods: The prescription was selected and optimized by the compatibility test and the pseudo-ternary phase diagram. The appearance character, pH value, viscosity, drug content, transdermal absorption, the anti-inflammatory and the antibacterial effect were evaluated. Results: The prescription was Flos Magnoliae oil (0.96%), Cremophor RH-40 (0.72%), transcutol P (0.72%), carbopol-980 (0.3%), and glycerol (0.3%) with distilled water added to 100 g. pH value was adjusted to 6.0 by triethanolamine. The obtained pH value was (6.00±0.01), the viscosity was (54 572±13.65) mPa?s and the oil drug concentration was (9.30±0.04) mg?g-1. The steady state penetration rate was 164.40 μg?cm-2?h-1 and the cumulative transdermal penetration per unit area was (4 034±125.03) μg?cm-2 after 48 h. The inhibition rate of auricular swelling in mice by the microemulsion gel was 58.33%, which was significantly different compared with the normal saline group (P<0.001). The diameters of inhibition zone for the microemulsion gel against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were (15.97±0.29), (15.07±0.12) and (15.73±0.25) mm, respectively. The preparation exhibited good stability, but needed to be kept in a cool place. Conclusion: The Flos Magnoliae-based oil microemulsion gel meets the requirement of the main indexes for topical drug delivery preparation. It has good anti-inflammatory and antibacterial effect, offering the basis for further research and development.
