摘要

目的检测新生大鼠缺氧缺血性脑病(HIE)模型血清神经特异性烯醇化酶(NSE)和视椎蛋白样蛋白1(VILIP-1)水平,为HIE早期诊断提供血清学参考指标。方法建立新生大鼠HIE模型,分为假手术组、对照组和治疗组;对照组建模后不予干预,治疗组建模后予维生素E灌胃,每组各48只新生大鼠。以ELISA法检测各组1、6、12、24、48和72h时点血清NSE和VILIP-1水平。以24h时点NSE和VILIP-1水平绘制ROC曲线。结果①对照组12、24、48h时点NSE水平显著高于假手术组,治疗组24、48和72h时点NSE水平显著低于对照组。②对照组12、24、48和72h时点VILIP-1水平均...

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