miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

作者：Carlos J. Rodriguez‐Ortiz; Gilberto Aleph Prieto; Alessandra C. Martini; Stefania Forner; Laura Trujillo‐Estrada; Frank M. LaFerla; David Baglietto‐Vargas; Carl W. Cotman; Masashi Kitazawa

来源：AGING CELL, 2020, 19(3).

DOI：10.1111/acel.13118

• AMPA receptor
• Amyloid‐beta oligomers
• GluA2
• Long‐term potentiation
• MicroRNAs
• Spatial memory
• Translin/trax

Abstract(#br)MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation of synaptic functions. Among them, recent emerging evidence highlights that microRNA‐181a (miR‐181a) is particularly abundant in hippocampal neurons and controls the expression of key plasticity‐related prote...