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摘要
Background: Hyperuricemia(HUA)and hypertension are important controllable risk factors for cardiovascular and cerebrovascular diseases.They often coexist with other cardiovascular risk factors,and accelerate the progression of cardiovascular disease.Objective: To investigate the incidence and influencing factors of HUA in hypertensive populations.Methods: We enrolled 3 930 physical examinees with hypertension from a physical examination center of Beijing from 2012 to 2016,and followed up them for 1 to 4 years.We analyzed the incidence of HUA in these participants,and compared the demographic,physical and laboratory data between non-HUA and HUA groups,and analyzed the influencing factors of HUA by using Logistic stepwise regression.Results: The incidence of HUA in the participants was 23.31%(916/3 930).Sex-specific analysis showed that the incidence of HUA was higher in males than that in females〔24.76%(742/2 997) vs 18.65%(174/933),χ2=14.853,P<0.001〕.Age-specific analysis indicated that the incidence of HUA was 25.67%(295 /1 149),21.76%(363/1 668),21.44%(149/695) and 26.08%(109/418) in age groups of <45,45-<60,60-<75 and ≥75,respectively.There was no significant difference in the cumulative incidence of HUA among different age groups(χ2=0.467,P=0.495).Compared with non-HUA group,HUA group showed higher proportion of males,higher mean levels of WBC,GGT,creatinine,triglyceride,uric acid,BMI,and waist-hip ratio,and lower mean ALT,HDL-C and FBG levels(P<0.05).Stepwise Logistic regression analysis showed that creatinine,HDL-C,triglyceride,FBG,erythrocyte sedimentation rate and obesity were factors associated with HUA in hypertensive populations(P<0.05),and hemoglobin,creatinine,HDL-C,triglyceride,FBG and obesity were factors associated with HUA in hypertensive men(P<0.05),and age,total cholesterol and obesity were factors associated with HUA in hypertensive women(P<0.05).Conclusion: The incidence of HUA does not increase with age in hypertensive populations.Factors associated with HUA in this group include creatinine,HDL-C,triglyceride,FBG,erythrocyte sedimentation rate,and obesity.Sex differences are also found in factors affecting the incidence of HUA.
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