科研之友
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摘要
objective: to study the clinical course of patients with a serum monoclonal protein at guadalajara health area. material and methods: prospective study of 186 patients with a newly diagnosed monoclonal component. they have been collected during the years 1999 and 2000. results: the cumulative transformation probability at 43 months was 4.99% for those patients whose monoclonal gammopathy was overlooked, and 2% at 23 months for patients with monoclonal gammopathy of undetermined significance. the cumulative probability of survival for patients with multiple myeloma was 66.7% at 21 months. the conditional mortality rate (patients/months) at 4 years due to haematological disease was 4.48x10-4 for overlooked patients, 0 for diagnosed of monoclonal gammopathy of undetermined significance and 1.388x10-2 for multiple myeloma diagnosed. discussion: a non malignant m component must be followed up due to it could increase patients%26apos; survival rate in relation with transformation in malignant disease.
