Effect of Shengmai Injection (生脉注射液) on Vascular Endothelial and Heart Functions in Patients with Coronary Heart Disease Complicated with Diabetes Mellitus

作者：张亚臣; 吕宝经; 赵美华; 荣烨之; 陈瑞明

来源：Chinese Journal of Integrative Medicine, 2008, 14(04): 281-285.

• Shengmai injection
• coronary heart disease
• diabetes mellitus
• vascular endothelial function
• heart function

<正>Objective:To study the effect of Shengmai injection(生脉注射液,SMI)on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM).Methods:One hundred and twenty patients with CHD-DM,their diagnosis confirmed by coronary arteriography,were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI.The changes in blood levels of nitric oxide(NO),endothelin-1(ET-1)and angiotensinⅡ(AngⅡ),as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment.Results:After being treated with SMI for 3 weeks,in the treated group,blood level of NO was raised significantly from 69.8±33.1μmol/L to 120.1±50.8μmol/L,and ET-1 was lowered from 70.1±32.1 ng/L to 46.2±21.3 ng/L,respectively(P<0.01);that of AngⅡwas lowered from 81.3±24.3 ng/L to 50.2±27.3 ng/L(P<0.01);brachial arterial post-congestion blood flow increasing rate was raised from 389.4±26.3% to 459.3±27.8%(P<0.01);and the improvement in heart function as seen through the ejection fraction(EF)was increased from 44±5% to 68±6%(P<0.01),all the changes being more significant than those in the control group(all P<0.01).Conclusion:SMI can improve not only the endothelial function in CHD-DM patients,but also heart contraction significantly.

• 单位
  上海交通大学