Efeito da terapia antirretroviral e dos n赤veis de carga viral no complexo m谷dio-intimal e no 赤ndice tornozelo-braˋo em pacientes infectados pelo HIV

作者：Godoi; Emmanuelle Tenorio Albuquerque Madruga; Brandt; Carlos Teixeira; Godoi; Jocelene Tenorio Albuquerque Madruga; Lacerda; Heloisa Ramos; Albuquerque; Valeria Maria Gonalves de; Zirpoli; Josefina Claudia; Godoi; Juannicelle Tenorio Albuquerque Madruga; Sarteschi; Camila

来源：Jornal Vascular Brasileiro, 2012.

DOI：10.1590/S1677-54492012000200009

• atherosclerosis
• ankle brachial index
• anti-retroviral agent.

objectives: to precociously identify the prevalence of atherosclerosis caused by thickening of the intima-media complex of the common carotid arteries and of the ankle brachial index. these measurements were associated with the classical risk factors of atherosclerosis and the specific factors of those infected by hiv (duration of disease, length of treatment, kind of treatment, kind of antiretroviral therapy used, cd4 and viral load). methods: seventy cases infected by hiv were assessed by automatic measurement of the intima-media complex in the carotids and of the ankle brachial index. the classical risk factors of atherosclerosis (age, gender, systemic arterial hypertension, smoking, hypercholesterolemia, hypertriglyceridemia, obesity, and family history of cardiovascular events), anthropometric measurements and the variables related to hiv were taken into consideration. the adopted level of significance was 5%. results: the mean time of hiv diagnosis was 104.9 months, mean duration of treatment was 97.9 months. as regard to the type of treatment, 47 (67.1%) used protease inhibitor for more than six months and 36 (51.4%) are using it recently. the ankle brachial index was increased in one patient (0.7%), and the intima-media complex was not thickened in any individual. there was no significant association of the measurement of the intima-media complex of the right common carotid with any of the variables analyzed. conclusions: young individuals under the use of antiretroviral therapy for five years or more did not show increase in thickness of the intima-media complex or increase in the ankle brachial index, and there was no difference in the intima-media complex thickness associated with the therapeutical scheme of antiretroviral used or the viral load level.