Application Value of Macrogene Ⅱ Sequencing in IPA Diagnosis and Treatment

作者:ZHOU Ting-ting; LI Yu-yan; SONG Li-ying; WANG Shuang-ge
来源:Chinese Journal of Biomedical Engineering, 2022, 31(01): 33-39.

摘要

Infectious diseases feature multiple pathogens, complicated and diverse clinical symptoms. Early and accurate detection of infectious pathogens sets the foundation for its targeted clinical treatment. With long detection cycles and low positive rates, traditional detection approaches such as Gram-stained smear microscopy and specific marker detection can barely meet the clinical needs for infectious disease detection. As a new gene detection technology, macrogene Ⅱ sequencing can enable higher detection efficiency for infectious diseases caused by pathogens such as fungi and bacteria, demonstrating certain application value. This paper describes invasive pulmonary aspergillosis(IPA), concepts concerning macrogene Ⅱ sequencing, as well as its application value for invasive pulmonary aspergillosis.