科研之友
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摘要
Objective: To evaluate the consistency of product quality between modern technology and traditional technology, to screen the modern extraction process parameters of Xiaoxuming Decoction (XXMD, 小续命汤) by using standard relation and analytic hierarchy process (AHP)-entropy method. Method: With the content of pseudoephedrine hydrochloride, baicalin, and paeoniflorin in XXMD as well as paste yielding rate and fingerprint similarity as evaluation indexes, orthogonal experiment was used to research extraction process of XXMD after solid-liquid ratio, extraction times and extraction time as factors. The concept of standard relation was introduced for the first time to calculate standard relation between each samples and standard decoction of various indexes of different extraction parameters, while AHP-entropy method was applied to determine the weight of each index for comprehensive score. Results: The modern extraction process parameters of XXMD, screened by using standard relation and AHP-entropy method, which was compound herbs extracted for 1 h with 12 times the amount of water. Six batches of comprehensive evaluation was greater than 94.12, RSD value was 1.87%, and meet the quality requirements of standard decoction. The parameter was consistent with the final mass production parameters in the actual practice. Conclusion: The results obtained in this study show the feasibility of standard relation combined with AHP-entropy method in selecting key process parameters, which can provide theoretical reference for the modern extraction research of other classical prescriptions.
