乳腺浸润性导管癌组织中HMGB1表达的临床意义(英文)

作者：Baoping Chang; Xiao Wang; Songsou Gao; Bianfeng Zhao; Wanli Wang; Shaohua Yang; Qian Chu; Shiying Yu

来源：The Chinese-German Journal of Clinical Oncology, 2014, 13(05): 215-219.

• infiltrating ductal carcinoma(IDC)
• high-mobility group box 1 protein(HMGB1)
• clinical staging
• lymph node
• estrogen receptor(ER)
• human epidermal growth factor receptor 2(HER-2)

Objective: Exploring the clinical signification of high-mobility group box 1 protein(HMGB1) expression in infiltrating ductal carcinoma(IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor(ER), progesterone receptor(PR) and human epidermal growth factor receptor 2(HER-2) were also analyzed. Results: Fortysix cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 , statistical significance was observed between HMGB1 expression with clinical staging(P < 0.01), lymph node metastasis(P < 0.01), breast cancer ER(P < 0.05) and HER-2(P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It’s promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis.

• 单位
  华中科技大学