科研之友
微信
新浪微博
Facebook
分享链接
摘要
A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag18(CF3COO)18(H2O)2}{Ag4(erlotinib)4}]n·7nCH3OH·3nH2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC50 values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC50 value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.
