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摘要
Purpose: The study aimed to investigate the use of dynamic contrast-enhanced magnetic resonance imaging (MRI)-derived permeability parameters for the differentiation of glioblastoma multiformes (GBMs), primary central nervous system lymphomas (PCNSLs), and brain metastatic tumors (MTs). @@@ Materials and methods: Seventy-five patients with histopathologically confirmed GBMs (n=38), PCNSLs (n =16) and MTs (n = 21) underwent dynamic contrast-enhanced MRIs before surgery. The volume transfer constant K-trans, the flux rate constant between extravascular extracellular space and plasma K-ep, the extravascular extracellular volume V-e and the fractional plasma volume V-p were measured within the entire contrast-enhancing tumor by extended Tofts model. A one-way analysis of variance was used to compare all of the parameters among these three tumors, followed by the post-hoc test. Receiver operating characteristic curves were constructed to evaluate the diagnostic performance of the permeability parameters. @@@ Results: Mean K-trans value and V-e value were significantly higher in PCNSLs than in GBMs (P < 0.001 and P = 0.011) and MTs (P < 0.001 and P < 0.001). No significant difference was observed in all of the permeability parameters between GBMs and MTs. According to the receiver operating characteristic analyses, both K-trans and V-e had good diagnostic performance for discriminating between PCNSLs and GBMs (the area under the curve: 0.847 and 0.785, respectively), as well as between PCNSLs and MTs (the area under the curve: 0.851 and 0.884, respectively). @@@ Conclusions: The K-trans and V-e derived from dynamic contrast-enhanced MRI facilitate the differentiation of PCNSLs from GBMs and MTs.
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