Osseointegration: Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis (Adv. Funct. Mater. 7/2021)

作者：Wang Zhenzhen; Niu Yiming; Tian Xuejiao; Yu Na; Yin Xiaoyu; Xing Zhen; Li Yurong; Dong Lei; Wang Chunming

来源：Advanced Functional Materials, 2021, 31(7): 2170043.

DOI：10.1002/adfm.202170043

• bioresponsive materials
• glucomannan polysaccharides
• macrophages
• osseointegration

In article number 2007408, Lei Dong, Chunming Wang, and co‐workers invent a “bridge‐burning” bioactive coating to sequentially turn on and off inflammation on bone implants. This coating first instructs host macrophages to activate bone cells to promote healing and then receives signals from bone cells to kill macrophages for higher safety. It improves bone‐implant integration in mice with osteoporosis.

• 单位
  南京大学; 医药生物技术国家重点实验室