科研之友
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摘要
objective: to study the characteristics of the venous thromboembolic disease (vtd) in a rural area of southern extremadura (spain). material and methods: prospective observational study of all patients diagnosed by objective methods of vtd in the only hospital in our area from november 2002 to november 2004. results: seventy-six patients were diagnosed of vtd: 35 (46.1%) with pulmonary thromboembolism and 41 (53.9%) with isolated deep vein thrombosis (dvt). the median age was 72.4 years (range 35-94 years), 51 (67.1%) were older than 70 years, and 43 (56.6%) were women. the annual incidence of vtd was 0.63 per 1,000 persons (0.74 per 1,000 persons in women and 0.54 per 1,000 persons in men). thirty-seven patients (48.7%) had %26quot;idiopathic%26quot; vtd. after a median follow-up of 5.5 months with anticoagulant therapy, 13 patients (17.1%) had dead. comorbidity and non %26quot;idiopathic%26quot; vtd were significantly more frequent in the dead patients. three patients (3.9%) presented probable recurrence, and all of them died. there were 4 cases (5.3%) of non-fatal severe hemorrhage. nine patients with isolated dvt did not require hospitalization, and there was no event in the follow-up. conclusions: the incidence of vtd may be lower in our area than in other geographical areas. vtd affects more frequently to elderly and women, and almost half of cases are %26quot;idiopathic%26quot;. the mortality is high, and it is related to the existence of comorbidity and non %26quot;idiopathic%26quot; vtd. the recurrences and the severe hemorrhages are not exceptional during the anticoagulant therapy. the ambulatory treatment of isolated dvt may be an option in selected patients.
