Gravidade das coinfecˋˋes virais em lactentes hospitalizados com infecˋˋo por v赤rus sincicial respirat車rio

作者：Paulis; Milena De; Gilio; Alfredo Elias; Ferraro; Alexandre Archanjo; Ferronato; Angela Esposito; Sacramento; Patricia Rossi do; Botosso; Viviane Fongaro; Oliveira; Danielle Bruna Leal de; Marinheiro; Juliana Cristina; Harsi; Charlotte Marianna; Durigon; Edison Luiz; Vieira; Sandra Elisabete

来源：Jornal de Pediatria, 2011.

DOI：10.1590/S0021-75572011000400006

• coinfections
• respiratory viruses
• infants.

objective: to compare the severity of single respiratory syncytial virus (rsv) infections with that of coinfections. methods: a historical cohort was studied, including hospitalized infants with acute rsv infection. nasopharyngeal aspirate samples were collected from all patients to detect eight respiratory viruses using molecular biology techniques. the following outcomes were analyzed: duration of hospitalization and of oxygen therapy, intensive care unit admission and need of mechanical ventilation. results were adjusted for confounding factors (prematurity, age and breastfeeding). results: a hundred and seventy six infants with bronchiolitis and/or pneumonia were included in the study. their median age was 4.5 months. a hundred and twenty one had single rsv infection and 55 had coinfections (24 rsv + adenovirus, 16 rsv + human metapneumovirus and 15 other less frequent viral associations). the four severity outcomes under study were similar in the group with single rsv infection and in the coinfection groups, independently of what virus was associated with rsv. conclusion: virus coinfections do not seem to affect the prognosis of hospitalized infants with acute rsv infection.