科研之友
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摘要
Ten compounds were isolated from the leaves of Rhizophora stylosa,one kind of mangrove plants distributed in the tropical and subtropical areas of the world.Their structures were identified as taraxerone(1),taraxerol(2),β-sitosterol(3),careaborin(4),cis-careaborin(5),β-daucosterol(6),isovanillic acid(7),protocatechuic acid(8),astilbin(9) and rutin(10),among which compound 9 and 10 were reported in this plant for the first time.Of these compounds,compound 2 has been confirmed to have the abilities to inhibit the growth of Hela and BGC-823 with IC_(50) of 73.4 μmol·L~(-1) and 73.3 μmol·L~(-1),respectively.Compound 5 could inhibit the growth of BGC-823 and MCF-7 with IC_(50) of 45.9 μmol·L~(-1) and 116.0 μmol·L~(-1),respectively.Compound 9 and 10 were firstly reported to stimulate the proliferation of mice splenic lymphocytes markedly in a dose-dependent manner.
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