Ectopic expression of PLC‐β2 in non‐invasive breast tumor cells plays a protective role against malignant progression and is correlated with the deregulation of miR‐146a

作者：Valeria Bertagnolo; Silvia Grassilli; Stefano Volinia; Yasamin Al‐Qassab; Federica Brugnoli; Federica Vezzali; Elisabetta Lambertini; Maria Palomba; Quirino Piubello; Enrico Orvieto; Cristina Natali; Maria Roberta Piva; Carlo Maria Croce; Silvano Capitani

来源：Molecular Carcinogenesis, 2019, 58(5): 708-721.

DOI：10.1002/mc.22964

• Breast tumor recurrence
• Ductal carcinoma in situ (DCIS)
• Epithelial‐to‐mesenchymal transition (EMT)
• MiR‐146a
• Phosphoinositide‐dependent phospholipase C beta 2 (PLC‐β2)

Cells in non‐invasive breast lesions are widely believed to possess molecular alterations that render them either susceptible or refractory to the acquisition of invasive capability. One such alteration could be the ectopic expression of the β2 isoform of phosphoinositide‐dependent phospholipase C (...

• 单位
  the Ohio State University; The Ohio State university; Ohio state university; The Ohio State University