Utility of Serum and Urine uPAR Levels for Diagnosis of Breast Cancer

作者：Soydinc Hilal Oguz; Duranyildiz Derya^*; Guney Nese; Derin Duygu; Yasasever Vildan

来源：Asian Pacific Journal of Cancer Prevention, 2012, 13(6): 2887-2889.

DOI：10.7314/APJCP.2012.13.6.2887

• Tumor markers
• biochemical markers
• breast cancer
• cancer biomarkers
• invasion %26 metastasis
• uPAR

Malignant tumors have a capacity to degrade the extracellular matrix by controlled proteolysis. One system involved in these processes is the urokinase-type plasminogen activator (uPA) system. uPAR levels are elevated in tumors from several types of cancer. Our study was planned to investigate serum and urine levels of uPAR in breast cancer patients (n=180) and healthy controls (n=60) by ELISA. Serum (p%26lt;0.001) and urine (p%26lt;0.001) uPAR values in the patients were both significantly elevated. High serum and urine levels of uPAR can be used as diagnostic tools in lymph node positive patients.