pH and Reactive Oxygen Species‐Sequential Responsive Nano‐in‐Micro Composite for Targeted Therapy of Inflammatory Bowel Disease

作者：Serena Bertoni; Zehua Liu; Alexandra Correia; Joo Pedro Martins; Antti Rahikkala; Flavia Fontana; Marianna Kemell; Dongfei Liu; Beatrice Albertini; Nadia Passerini; Wei Li; Hélder A Santos

来源：Advanced Functional Materials, 2018, 28(50): 1806175.

DOI：10.1002/adfm.201806175

• Inflammatory bowel disease
• Microfluidics
• Nanoparticles
• Oxidation‐responsive
• ROS‐responsive delivery

Abstract(#br)Oxidative stress and abnormally high levels of reactive oxygen species (ROS) play an essential role in the pathogenesis and progression of inflammatory bowel disease (IBD). Oxidation‐responsive nanoparticles (NPs) are formulated from a phenylboronic esters‐modified dextran (OxiDEX) that...